Primary closed angle glaucoma (PCAG)/primary angle closure glaucoma (PAGC) Pilot Project

 

Primary closed angle glaucoma (PCAG) / primary angle closure glaucoma (PAGC) is significantly associated with defective development of the drainage angle which is termed goniodysgenesis (gonio = angle, dysgenesis = defective development), also known as Pectinate Ligament Dysplasia (PLD) or Pectinate Ligament Abnormality (PLA). Goniodysgenesis is inherited in several breeds and is tested for using a technique called gonioscopy. It was originally believed that the degree of goniodysgenesis did not progress after birth and so a ‘one-off’ test before breeding was advised for dogs of certified breeds. However, recent research has provided evidence of progression of goniodysgenesis with age in several breeds, namely the Flat Coated Retriever, Welsh Springer Spaniel, Dandie Dinmont Terrier, Basset Hound and Leonberger. In consequence, the advice on gonioscopy has been updated for all breeds in which gonioscopy is performed. It is advised that for Schedule A breeds gonioscopy should be carried out every 3 years, unless any evidence to the contrary emerges. The first test can be performed in dogs from 6 months of age onwards and current advice is that gonioscopy is performed at approximately 1, 4 and 7-8 years of age. Repeat testing should provide much needed longitudinal information about the risk of developing glaucoma in later life and, in conjunction with Breed Clubs, will enable breed-specific recommendations to be developed.

 

A simple grading scheme (0-3) for gonioscopy was agreed by the Eye Panel Working Party in 2016; it is being piloted from July 2017 with the aim of being formally adopted, with or without any revisions, if analysis of the results supports this approach. Initial analysis will take place at around the time of the next Eye Panel Working Party (EPWP) meeting in November 2017. The grading scheme will be used to complement - and may ultimately replace - the ‘Clinically Unaffected’ or ‘Clinically Affected’ classification that currently records the results of examination. The EPWP has proposed that a grading system reflects more accurately what the Panellist observes and is better able to inform the potential risk of developing glaucoma in later life. It will provide owners with useful information to aid breeding decisions. The grading proposal is, in part, also a recognition that ‘Clinically Unaffected’ cannot be an accurate description unless the gonioscopic findings are entirely normal.

 

The Kennel Club database is not set up to record grades, so the pilot gonioscopy grading project will run in parallel with the existing layout of the Certificate of Eye Examination. The recording of results as ‘Clinically Unaffected’ and ‘Clinically Affected’ under Goniodysgenesis (G) continues as before for the benefit of the Kennel Club and the results will be published as they are at present. The grades will be recorded and collated by the BVA

 

Protocol to be followed for the Pilot Grading Project

 

On the Certificate of Eye Examination

 

Second section: EXAMINATION OF THE EYE AND ADNEXA

 

Gonioscopy grading recorded under Descriptive Comments

 

0

1

2

3

 

 

 

 

Tick one box

Should there be disparity between the grade assessments in each eye, it is the higher value that is recorded on the Certificate of Eye Examination under Descriptive comments.

 

 

Third section: INHERITED EYE DISEASE STATUS – SCHEDULE A BREEDS ONLY

 

                                                            CLINICALLY         CLINICALLY

                                                                                UNAFFECTED     AFFECTED

 

(G) Goniodysgenesis                                                                  

Tick one box as at present

 

 

 

Summary

 

Grade

Gonioscopic findings

Diagnosis

0

Normal iridocorneal angle (ICA) with no/minimal (0%-<1%) pectinate ligament abnormality (PLA)

Advice: Normal iridocorneal angle -highly unlikely to develop primary glaucoma

Currently classified for KC publication as ‘Clinically Unaffected’

1

1-25% of ICA affected by PLA

Advice: mildly affected - unlikely to develop primary glaucoma

Currently classified for KC publication as ‘Clinically Unaffected’

2

26-75% of ICA affected by PLA

Advice: moderately affected - low risk of developing primary glaucoma

Currently classified for KC publication as ‘Clinically Unaffected’

3

>75% of ICA affected, and/or severe narrowing of ICA

Advice: severely affected - highest risk of developing primary glaucoma, breeding not recommended

Currently classified for KC publication as ‘Clinically Affected’

 

 

 

 

 

 

 

HEALTH REPORT FROM THE MEETING OF THE

WSS JOINT HEALTH GROUP

HELD ON 5th MARCH 2017

 

GLAUCOMA

There has been one further report of a dog who has developed Glaucoma:

HELGEN CONFETTI .

The Group would like to remind you that it is now been recommended that dogs are tested every 3 years for Goniodysgenesis, and preferably before breeding.

 

CANINE GENOME PROJECT

As part of the ongoing Canine Genome Project we have now been advised that they are focusing on Epilepsy in the Welsh Springer Spaniel.  We have therefore been requested to provide the names of 3 fitting dogs, still living, who have undergone the full criteria of clinical tests including an MRI.  Initially a DNA cheek swab sample will be required.

If you know of a suitable dog, whose owner would be willing to help, the JHG Secretary would be pleased to hear from you on julita@furzelands.demon.co.uk.

 

CANCER

The Group has agreed to take part in a survey re Cancer, being organised by the university of Nottingham on Spaniels.  The Breed Clubs will be sending out questionnaires to their Members at a later date.

 

MENINGITIS

As there have been a number of reports of Meningitis within the Welsh Springer Spaniel community, the JHG would be interested to hear of any Welsh Springer Spaniel who has been diagnosed with this condition.  Please contact the JHG Secretary on julita@furzelands.demon.co.uk .

 

 

Julie Revill

Secretary

WSS Joint Health Group